Chonluten Nasal Spray
20 mg of the Khavinson tripeptide Glu-Asp-Gly (EDG) as a sterile solution in bacteriostatic water, in a metered spray bottle. Made from a peptide lot tested in the manufacturer’s own laboratory, with a certificate.
| Compound | Chonluten Glu-Asp-Gly (EDG); Khavinson bronchial-mucosa peptide bioregulator |
|---|---|
| CAS number | 75007-24-8 |
| Molecular formula | C11H17N3O8 |
| Theoretical mass | 319.3 Da |
| Sequence / structure | H-EDG-OH (3 residues; free N- and C-termini) |
| Contents | Chonluten: 20 mg per bottle (≤ 0.2% w/v) |
| Form | Sterile aqueous solution in bacteriostatic water (0.9% benzyl alcohol), supplied in a metered nasal spray bottle |
| Storage, sealed | Store at 2–8 °C, protected from light; do not freeze |
| Format | Solution in a metered nasal spray bottle |
Sizes and lots
- 20 mg · 1 bottle — $118.99
- 20 mg · Kit of 10 — $1057.82
Chonluten nasal spray holds Glu-Asp-Gly, the 319.3 Da tripeptide that Khavinson's bioregulator series links to the bronchial mucosa. The bottle contains 20 mg of Chonluten in sterile bacteriostatic water, at no more than 0.2% w/v by the safety data sheet, already in solution. Research on the peptide is limited to cell work, chiefly one study of TNF and IL-6 in a human monocyte line, and none of it has looked at the nasal route.
What is in the bottle
The solution contains 20 mg of the Chonluten tripeptide, identical to the powder in the Chonluten 20 mg vial, at or below 0.2% w/v. It is made up in bacteriostatic water preserved with 0.9% benzyl alcohol. The safety data sheet does not classify Chonluten as hazardous; the benzyl alcohol is listed as harmful by mouth or inhalation, an eye irritant and a potential skin sensitiser.
Keep the bottle upright, capped and at 2 to 8 °C, away from light, and do not freeze it. Chonluten begins with a glutamic acid, and an N-terminal glutamate can cyclise to pyroglutamate in water, a reaction detected in antibodies after a few weeks at 37 and 45 °C1. General guidance on peptide solutions is in peptide storage and stability.
What the research covers
In Khavinson's framework, short peptides like Chonluten act inside the nucleus, binding histones and DNA and changing gene expression and methylation2. The direct evidence for Chonluten is narrower. Avolio and colleagues found that it inhibited TNF production in THP-1 human monocytes challenged with lipopolysaccharide, and that it and four other Khavinson peptides lowered TNF and IL-6 expression in the same line after differentiation into macrophages3.
The airway findings often attached to the series mostly come from another peptide. In human embryonic bronchial epithelial cultures, the tetrapeptide ADEL changed levels of Ki67, Mcl-1, p53 and NOS-3 and the expression of differentiation genes such as NKX2-1 and FOXA1, with the strongest effect on proliferation in late-passage cultures4. Chonluten was not part of that study, and its own results come from immune cells rather than airway tissue.
Frequently asked questions
Is the spray the same peptide as the Chonluten vial?
Yes. The vial, pen and spray all contain Glu-Asp-Gly. The vial is freeze-dried and kept frozen, while the spray is a sterile solution in bacteriostatic water kept between 2 and 8 °C. The spray and the vial each contain 20 mg, as does the pen.
How much Chonluten is in the bottle?
Twenty milligrams, at no more than 0.2% w/v according to the safety data sheet, with the amount on the bottle label. Where a study needs its own concentration, the vial provides a stated mass of dry peptide instead.
Has Chonluten been studied in the nose or airways?
Not in the references checked for this page. The measured Chonluten work is in a monocyte cell line, and the bronchial epithelial study often quoted for the series tested a different peptide, ADEL.
References
- Chelius D, Jing K, Lueras A, et al. Formation of pyroglutamic acid from N-terminal glutamic acid in immunoglobulin gamma antibodies. Anal Chem. 2006;78(7):2370-6. DOI · PubMed
- Khavinson VK, Popovich IG, Linkova NS, et al. Peptide Regulation of Gene Expression: A Systematic Review. Molecules. 2021;26(22). DOI · PubMed
- Avolio F, Martinotti S, Khavinson VK, et al. Peptides Regulating Proliferative Activity and Inflammatory Pathways in the Monocyte/Macrophage THP-1 Cell Line. Int J Mol Sci. 2022;23(7). DOI · PubMed
- Khavinson VKh, Tendler SM, Vanyushin BF, et al. Peptide regulation of gene expression and protein synthesis in bronchial epithelium. Lung. 2014;192(5):781-91. DOI · PubMed
For laboratory research use only. Not for human or veterinary consumption. Products have not been evaluated by the U.S. Food and Drug Administration and are not intended to diagnose, treat, cure or prevent any disease.