Chonluten Pen
20 mg of the Khavinson tripeptide in 3 mL of sterile bacteriostatic water, 0.67% w/v. Filled from a peptide lot tested in the manufacturer’s own laboratory, with a certificate.
| Compound | Chonluten Glu-Asp-Gly (EDG); Khavinson bronchial-mucosa peptide bioregulator |
|---|---|
| CAS number | 75007-24-8 |
| Molecular formula | C11H17N3O8 |
| Theoretical mass | 319.3 Da |
| Sequence / structure | H-EDG-OH (3 residues; free N- and C-termini) |
| Contents | Chonluten: 20 mg per 3 mL pen (0.67% w/v) |
| Form | Sterile aqueous solution in bacteriostatic water (0.9% benzyl alcohol), supplied in a 3 mL glass cartridge inside a preloaded autoinjector pen fitted with a needle |
| Storage, sealed | Store at 2–8 °C in the original carton, protected from light |
| Format | Solution in a 3 mL pre-filled pen |
Sizes and lots
- 20 mg · 1 pen — $68.99
- 20 mg · Kit of 10 — $613.32
Chonluten, the Khavinson tripeptide Glu-Asp-Gly (EDG, CAS 75007-24-8), comes in this listing as a preloaded pen: a 3 mL cartridge holding 20 mg of Chonluten in sterile bacteriostatic water at 0.67% w/v. Its published research is short and mostly cellular, led by a 2022 study of inflammatory signalling in a human monocyte cell line. Because the sequence contains an Asp-Gly bond, how the peptide behaves in water matters more for a ready-made solution than for dry powder.
What is in the pen
The cartridge contains 3 mL of sterile solution with 20 mg of the same H-EDG-OH sold freeze-dried in the Chonluten 20 mg vial. At 0.67% w/v the concentration is about 6.7 mg/mL, and the whole pen holds roughly 63 µmol. The vehicle is bacteriostatic water with 0.9% benzyl alcohol. The safety data sheet classes the peptide as non-hazardous and gives benzyl alcohol hazard statements for oral and inhalation toxicity, eye irritation and skin sensitisation.
Keep the pen cold, at 2 to 8 °C in its carton and out of light, capped once opened, and never frozen; discard it if the solution freezes, discolours or turns cloudy. Unlike the vial, the pen holds the peptide in water from the day it is filled. Peptide pen vs vial compares the two formats in general.
What the research covers
The clearest Chonluten finding comes from a cell line. Avolio and colleagues, with Khavinson as a co-author, exposed human THP-1 monocytes to five Khavinson peptides; Chonluten reduced TNF release when the cells were challenged with bacterial lipopolysaccharide, and in macrophage-differentiated THP-1 cells all five peptides lowered LPS-driven TNF and IL-6 expression1. An earlier paper from St Petersburg reported that the peptide coded T-34, which the Chonluten guide equates with EDG, regulated genes for antioxidant and anti-inflammatory proteins in a gastric ulcer setting2.
For a solution format, the chemistry of the sequence is as relevant as the biology. In a model hexapeptide with the same Asp-Gly linkage, degradation in water depended on pH: very acidic conditions mostly broke the Asp-Gly bond, while at pH 4 to 5 the peptide also isomerised to its iso-aspartate form3. None of the references here measured these reactions for Chonluten, and no stability data for the pen have been published.
Frequently asked questions
How does the pen compare with the Chonluten vial?
Both hold 20 mg of Glu-Asp-Gly. The vial is dry powder stored at −20 °C; the pen is a solution at about 6.7 mg/mL in bacteriostatic water, stored at 2 to 8 °C. A dry powder keeps the Asp-Gly bond out of water until the lab chooses to dissolve it.
Is anything known about Chonluten's stability in solution?
Not directly. The cited chemistry papers studied model peptides and antibodies, not Chonluten, but they show that Asp-Gly bonds and N-terminal glutamate both change in water depending on pH. For the pen, follow the safety data sheet: cold, dark and never frozen.
References
- Avolio F, Martinotti S, Khavinson VK, et al. Peptides Regulating Proliferative Activity and Inflammatory Pathways in the Monocyte/Macrophage THP-1 Cell Line. Int J Mol Sci. 2022;23(7). DOI · PubMed
- Khavinson VKh, Lin'kova NS, Dudkov AV, et al. Peptidergic regulation of expression of genes encoding antioxidant and anti-inflammatory proteins. Bull Exp Biol Med. 2012;152(5):615-8. DOI · PubMed
- Oliyai C, Borchardt RT. Chemical pathways of peptide degradation. IV. Pathways, kinetics, and mechanism of degradation of an aspartyl residue in a model hexapeptide. Pharm Res. 1993;10(1):95-102. DOI · PubMed
For laboratory research use only. Not for human or veterinary consumption. Products have not been evaluated by the U.S. Food and Drug Administration and are not intended to diagnose, treat, cure or prevent any disease.