Epithalon Nasal Spray
The synthetic Ala-Glu-Asp-Gly tetrapeptide as a sterile solution in bacteriostatic water, in a metered spray bottle. Made from a peptide lot tested in the manufacturer’s own laboratory, with a certificate.
| Compound | Epitalon Epithalon; Ala-Glu-Asp-Gly (AEDG); Khavinson pineal peptide bioregulator |
|---|---|
| CAS number | 307297-39-8 |
| Molecular formula | C14H22N4O9 |
| Theoretical mass | 390.4 Da |
| Sequence / structure | H-AEDG-OH (4 residues; free N- and C-termini) |
| Contents | Epitalon: 10 mg per bottle (≤ 0.1% w/v) |
| Form | Sterile aqueous solution in bacteriostatic water (0.9% benzyl alcohol), supplied in a metered nasal spray bottle |
| Storage, sealed | Store at 2–8 °C, protected from light; do not freeze |
| Format | Solution in a metered nasal spray bottle |
Sizes and lots
- 10 mg · 1 bottle — $88.99
- 10 mg · Kit of 10 — $791.12
Epitalon, also written Epithalon, is a synthetic four-residue peptide, Ala-Glu-Asp-Gly, created in St Petersburg as a defined stand-in for the pineal extract epithalamin. Here it is supplied as a sterile solution, 10 mg in a metered nasal spray bottle. Research on Epitalon covers telomerase in cell culture and survival and tumour endpoints in mice and rats. None of the studies cited on this page delivered it through the nose.
What is in the bottle
The bottle holds 10 mg of Epitalon dissolved in bacteriostatic water with 0.9% benzyl alcohol as a preservative, and the safety data sheet puts the peptide at no more than 0.1% w/v. Epitalon itself is not classified as hazardous. Benzyl alcohol is: it is harmful if swallowed or inhaled, seriously irritates the eyes and may cause an allergic skin reaction.
Keep the bottle upright and capped at 2 to 8 °C, out of the light, and never freeze it. In water, the aspartate-glycine pair at the end of the peptide can slowly convert to an isomer of identical mass, a reaction measured in an Asp-Gly model peptide1, so cold storage matters more for the spray than for the dry vials. General advice on peptide solutions is in peptide storage and stability.
What the research covers
The sequence was drawn from the amino-acid composition of epithalamin, and a 2025 review found reports of effects on melatonin synthesis, cytokine mRNA, thymocyte activity and telomerase, with the mechanism left open2. The reviewers also noted that physical and structural work on the peptide is scarce2. In the original cell-culture study, published in 2003, telomerase-negative human fetal fibroblasts exposed to Epitalon expressed the telomerase catalytic subunit, gained enzyme activity and showed telomere elongation3. Its authors took this as a sign that the telomerase gene had been switched back on in somatic cells3, an interpretation drawn from cultured fibroblasts alone. In female SHR mice followed for life, the peptide left mean lifespan unchanged, added 12.3% to maximum lifespan and lowered the frequency of chromosome aberrations and leukaemia4. That study used 54 mice per group, a modest size for a lifespan experiment4.
Frequently asked questions
Is the spray the same peptide as the vials and pen?
Yes, the same Ala-Glu-Asp-Gly tetrapeptide with free termini. The vials are freeze-dried powder kept frozen; the spray is a ready-made solution in bacteriostatic water that is kept cold but never frozen, with 10 mg of peptide in the bottle.
Has Epitalon been studied as a nasal spray?
Not in any paper cited here. The published work used cell cultures and rodents, and none of it measured nasal uptake of the peptide, so there are no findings specific to this format to report.
References
- Oliyai C, Borchardt RT. Chemical pathways of peptide degradation. IV. Pathways, kinetics, and mechanism of degradation of an aspartyl residue in a model hexapeptide. Pharm Res. 1993;10(1):95-102. DOI · PubMed
- Araj SK, Brzezik J, Mądra-Gackowska K, et al. Overview of Epitalon-Highly Bioactive Pineal Tetrapeptide with Promising Properties. Int J Mol Sci. 2025;26(6). DOI · PubMed
- Khavinson VKh, Bondarev IE, Butyugov AA. Epithalon peptide induces telomerase activity and telomere elongation in human somatic cells. Bull Exp Biol Med. 2003;135(6):590-2. DOI · PubMed
- Anisimov VN, Khavinson VKh, Popovich IG, et al. Effect of Epitalon on biomarkers of aging, life span and spontaneous tumor incidence in female Swiss-derived SHR mice. Biogerontology. 2003;4(4):193-202. DOI · PubMed
For laboratory research use only. Not for human or veterinary consumption. Products have not been evaluated by the U.S. Food and Drug Administration and are not intended to diagnose, treat, cure or prevent any disease.