GHRP-6 Nasal Spray
10 mg of the six-residue growth hormone secretagogue His-D-Trp-Ala-Trp-D-Phe-Lys-NH2 in bacteriostatic water, in a spray bottle. Made from a peptide lot tested in the manufacturer’s own laboratory, with a certificate.
| Compound | GHRP-6 Growth hormone-releasing peptide-6 |
|---|---|
| CAS number | 87616-84-0 |
| Molecular formula | C46H56N12O6 |
| Theoretical mass | 873.0 Da |
| Sequence / structure | H-H-[D-Trp]-A-W-[D-Phe]-K-NH₂ (6 residues; C-terminal amide) |
| Contents | GHRP-6: 10 mg per bottle (≤ 0.1% w/v) |
| Form | Sterile aqueous solution in bacteriostatic water (0.9% benzyl alcohol), supplied in a metered nasal spray bottle |
| Storage, sealed | Store at 2–8 °C, protected from light; do not freeze |
| Format | Solution in a metered nasal spray bottle |
Sizes and lots
- 10 mg · 1 bottle — $53.99
- 10 mg · Kit of 10 — $479.97
GHRP-6 is a synthetic six-residue peptide, His-D-Trp-Ala-Trp-D-Phe-Lys-NH2, that releases growth hormone by acting at the growth hormone secretagogue receptor. This listing is 10 mg of GHRP-6 dissolved in bacteriostatic water and supplied in a nasal spray bottle. Research on the peptide concerns growth hormone release in animals and people and the receptor and natural ligand it led researchers to; nasal delivery of GHRP-6 is not covered by the papers cited here.
What is in the bottle
The safety data sheet gives the contents as 10 mg of GHRP-6 per bottle at no more than 0.1% w/v, in bacteriostatic water: sterile water with 0.9% w/v benzyl alcohol as an antimicrobial preservative. GHRP-6 itself is not classified as hazardous. Benzyl alcohol is classified as harmful if swallowed or inhaled, a serious eye irritant and a skin sensitiser. Keep the bottle upright and capped at 2 to 8 °C, protected from light, and never freeze it. The same peptide is available as dry powder in the GHRP-6 5 mg vial.
What the research covers
GHRP-6 predates the receptor it acts on. When Howard and colleagues cloned the growth hormone secretagogue receptor in 1996, from pig and human pituitary and hypothalamus, they concluded that the synthetic secretagogues were standing in for a hormone nobody had yet found1. Kojima's group isolated that hormone, ghrelin, from rat stomach three years later; its activity depends on an octanoyl group attached to serine 32. Ghrelin given to rats increased food intake as well as growth hormone3, and that result is the main basis for describing GHRP-6 as an appetite-stimulating peptide, although none of the abstracts here measured feeding after GHRP-6 itself.
Nasal delivery is a separate question with no data on this page. None of the cited papers gave GHRP-6 through the nose, so how much of an 873 Da hexapeptide crosses the nasal lining, and how quickly, is not established here. The discovery work, the early human studies and the pharmacokinetics measured in healthy men are summarised on the GHRP-6 10 mg vial page, and the GHRP-2 vs GHRP-6 guide compares it with GHRP-2.
Frequently asked questions
How much GHRP-6 does the bottle contain?
10 mg, according to the safety data sheet, at a concentration of no more than 0.1% w/v. For work that needs a different concentration, the 5 mg and 10 mg vials supply dry GHRP-6 that can be dissolved in whatever volume the experiment requires.
How is the spray different from the vials?
Same peptide, different state. The vials hold freeze-dried GHRP-6 that is stored at −20 °C. The spray holds it already dissolved in bacteriostatic water with benzyl alcohol as preservative, and it is kept at 2 to 8 °C and never frozen.
Has GHRP-6 been studied as a nasal spray?
Not in the papers cited on this page. The human data here come from studies that measured growth hormone or plasma levels after other routes, so no published finding specific to nasal delivery of GHRP-6 is available to report.
References
- Howard AD, Feighner SD, Cully DF, et al. A receptor in pituitary and hypothalamus that functions in growth hormone release. Science. 1996;273(5277):974-7. DOI · PubMed
- Kojima M, Hosoda H, Date Y, et al. Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature. 1999;402(6762):656-60. DOI · PubMed
- Wren AM, Small CJ, Ward HL, et al. The novel hypothalamic peptide ghrelin stimulates food intake and growth hormone secretion. Endocrinology. 2000;141(11):4325-8. DOI · PubMed
For laboratory research use only. Not for human or veterinary consumption. Products have not been evaluated by the U.S. Food and Drug Administration and are not intended to diagnose, treat, cure or prevent any disease.