GHRP-6 Pen
10 mg of the hexapeptide growth hormone secretagogue His-D-Trp-Ala-Trp-D-Phe-Lys-NH2 in solution, in a 3 mL autoinjector cartridge. Filled from a peptide lot tested in the manufacturer’s own laboratory, with a certificate.
| Compound | GHRP-6 Growth hormone-releasing peptide-6 |
|---|---|
| CAS number | 87616-84-0 |
| Molecular formula | C46H56N12O6 |
| Theoretical mass | 873.0 Da |
| Sequence / structure | H-H-[D-Trp]-A-W-[D-Phe]-K-NH₂ (6 residues; C-terminal amide) |
| Contents | GHRP-6: 10 mg per 3 mL pen (0.33% w/v) |
| Form | Sterile aqueous solution in bacteriostatic water (0.9% benzyl alcohol), supplied in a 3 mL glass cartridge inside a preloaded autoinjector pen fitted with a needle |
| Storage, sealed | Store at 2–8 °C in the original carton, protected from light |
| Format | Solution in a 3 mL pre-filled pen |
Sizes and lots
- 10 mg · 1 pen — $58.99
- 10 mg · Kit of 10 — $524.42
GHRP-6 is the hexapeptide His-D-Trp-Ala-Trp-D-Phe-Lys-NH2, a synthetic growth hormone secretagogue that acts at the ghrelin receptor. This listing is a preloaded autoinjector pen containing 10 mg of GHRP-6 in solution in a 3 mL cartridge, ready made rather than freeze-dried. Studies of GHRP-6 cover its pituitary action in animals and people, its pharmacokinetics in healthy men and, through the closely related hexarelin, a second binding protein in the heart.
What is in the pen
Per the listing, each pen holds 10 mg of GHRP-6 in a 3 mL cartridge. The peptide is the one sold freeze-dried in the GHRP-6 10 mg vial: six residues, a C-terminal amide and a theoretical mass of 873.0 Da, so 10 mg is about 11.5 µmol.
The sheet for GHRP-6 in solution, written for the nasal spray, gives storage at 2 to 8 °C, protected from light and not frozen. With two tryptophans in the sequence, keeping a cartridge of solution out of the light is part of keeping it intact. Peptide pen vs vial sets out the general differences between the two formats.
What the research covers
GHRP-6 belongs to a class that Bowers, reviewing it in 1998, described as releasing growth hormone through a dual, complementary action on the hypothalamus and the pituitary1. In the one detailed pharmacokinetic study cited here, covering nine healthy men, plasma GHRP-6 fell in two phases, with a distribution half-life of 7.6 minutes and an elimination half-life of 2.5 hours2.
The class also has a binding partner outside the pituitary. Bodart and colleagues labelled rat heart membranes with a photoactivatable form of hexarelin, a GHRP-6 analogue carrying one extra methyl group, and identified the 84 kDa binding protein as CD36, a glycoprotein on heart muscle cells and microvascular endothelial cells3. In perfused hearts hexarelin raised coronary perfusion pressure, and the effect was missing in hearts lacking CD363. The abstract does not show whether GHRP-6 binds CD36 to the same extent.
None of this work used a ready-made solution or addressed how long GHRP-6 stays intact in water. The GHRP-6 10 mg vial page has the full summary of the discovery and the human studies.
Frequently asked questions
What is the difference between the pen and the GHRP-6 vials?
The vials contain dry GHRP-6, stored frozen and dissolved when needed at a concentration you choose. The pen contains 10 mg already dissolved in a 3 mL cartridge, so the concentration is set and the peptide is stored as a solution, cold but never frozen.
How should the pen be stored?
Keep it in its packaging away from light, since the two tryptophan residues in GHRP-6 are sensitive to it.
References
- Bowers CY. Growth hormone-releasing peptide (GHRP). Cell Mol Life Sci. 1998;54(12):1316-29. DOI · PubMed
- Cabrales A, Gil J, Fernández E, et al. Pharmacokinetic study of Growth Hormone-Releasing Peptide 6 (GHRP-6) in nine male healthy volunteers. Eur J Pharm Sci. 2013;48(1-2):40-6. DOI · PubMed
- Bodart V, Febbraio M, Demers A, et al. CD36 mediates the cardiovascular action of growth hormone-releasing peptides in the heart. Circ Res. 2002;90(8):844-9. DOI · PubMed
For laboratory research use only. Not for human or veterinary consumption. Products have not been evaluated by the U.S. Food and Drug Administration and are not intended to diagnose, treat, cure or prevent any disease.