GKP Blend Pen
GHK-Cu 150 mg, KPV 30 mg and BPC-157 30 mg dissolved in 3 mL of bacteriostatic water, 70 mg/mL total. Filled from a peptide lot tested in the manufacturer’s own laboratory, with a certificate.
| Components | GHK-Cu (Copper tripeptide-1; Gly-His-Lys · Cu(II))KPV (Lys-Pro-Val; α-MSH(11–13))BPC-157 (Body Protection Compound-157; pentadecapeptide) |
|---|---|
| GHK-Cu CAS number | 89030-95-5 |
| KPV CAS number | 67727-97-3 |
| BPC-157 CAS number | 137525-51-0 |
| Contents | GHK-Cu: 150 mg per 3 mL pen (5% w/v)KPV: 30 mg per 3 mL pen (1% w/v)BPC-157: 30 mg per 3 mL pen (1% w/v) |
| Form | Sterile aqueous solution in bacteriostatic water (0.9% benzyl alcohol), supplied in a 3 mL glass cartridge inside a preloaded autoinjector pen fitted with a needle |
| Storage, sealed | Store at 2–8 °C in the original carton, protected from light |
| Format | Solution in a 3 mL pre-filled pen |
Sizes and lots
- 210 mg · 1 pen — $158.99
- 210 mg · Kit of 10 — $1487.99
This preloaded pen holds the GKP blend in solution: GHK-Cu, KPV and BPC-157 dissolved together at 70 mg/mL, 210 mg across 3 mL, in the same 5:1:1 proportion as the 70 mg vial. GHK-Cu has been studied for collagen and matrix effects, KPV for intestinal inflammation and BPC-157 for gut, tendon and blood vessel repair in rats. Nobody has studied the three combined.
What is in the pen
Per the pen's safety data sheet, each 3 mL cartridge contains GHK-Cu 150 mg (5% w/v), KPV 30 mg (1% w/v) and BPC-157 30 mg (1% w/v) in bacteriostatic water with 0.9% benzyl alcohol. Benzyl alcohol is the only classified ingredient, listed as harmful if swallowed or inhaled, a serious eye irritant and a possible skin sensitiser. The copper complex gives a clear blue to blue-violet solution.
Keep the pen cold, at 2 to 8 °C, in its carton and out of light, and cap it between uses. It must not freeze; discard a pen whose contents have frozen, changed colour or gone cloudy. For work at a concentration of your choosing, the freeze-dried GKP Blend 70 mg vial holds the same three peptides.
What the research covers
The three peptides in the pen were each studied separately. Reviews of GHK, the copper-binding plasma tripeptide, report increased collagen, elastin and glycosaminoglycan synthesis, support of dermal fibroblasts, and anti-inflammatory actions that include suppression of NF-κB1. The same 2018 review lists blood vessel and nerve outgrowth and repair of skin, bone and liver among its effects1. KPV, the alpha-MSH fragment Lys-Pro-Val, shortened the course of dextran sodium sulfate colitis in mice and lowered colonic inflammatory infiltrates and myeloperoxidase activity, and mice with T-cell transfer colitis also recovered under KPV2. For BPC-157, a review by Sikiric's group describes protection against alcohol- and NSAID-induced lesions along the rat gastrointestinal tract, angiogenic activity and interactions with the nitric oxide system3. The review calls BPC-157 stable in human gastric juice and reports no toxicity, but it comes from the group that produced much of the rat work3.
That is the whole of the evidence base: separate cell and animal studies, none using a combined solution. There are no published data on the stability of GHK-Cu, KPV and BPC-157 together in bacteriostatic water, or on whether the copper complex changes the other two over time. The KLOW peptide guide discusses all three components at length.
Frequently asked questions
How does the GKP pen compare with the GKP vial?
Same three peptides, same 5:1:1 mass ratio. The vial holds 70 mg as freeze-dried powder for storage at −20 °C and reconstitution in the lab; the pen holds 210 mg already dissolved at 70 mg/mL in bacteriostatic water, kept at 2 to 8 °C.
Why is the solution blue?
GHK-Cu carries a bound copper(II) ion, and that complex colours the solution clear blue to blue-violet. A solution that has changed colour, turned cloudy or been frozen should be discarded, as the safety data sheet directs.
References
- Pickart L, Margolina A. Regenerative and Protective Actions of the GHK-Cu Peptide in the Light of the New Gene Data. Int J Mol Sci. 2018;19(7). DOI · PubMed
- Kannengiesser K, Maaser C, Heidemann J, et al. Melanocortin-derived tripeptide KPV has anti-inflammatory potential in murine models of inflammatory bowel disease. Inflamm Bowel Dis. 2008;14(3):324-31. DOI · PubMed
- Sikiric P, Seiwerth S, Rucman R, et al. Stable gastric pentadecapeptide BPC 157: novel therapy in gastrointestinal tract. Curr Pharm Des. 2011;17(16):1612-32. DOI · PubMed
For laboratory research use only. Not for human or veterinary consumption. Products have not been evaluated by the U.S. Food and Drug Administration and are not intended to diagnose, treat, cure or prevent any disease.