Gonadorelin Nasal Spray
10 mg of synthetic native GnRH as a sterile solution in bacteriostatic water, in a metered spray bottle. Filled from a peptide lot tested in the manufacturer’s own laboratory, with a certificate.
| Compound | Gonadorelin Native gonadotropin-releasing hormone (GnRH, LHRH) |
|---|---|
| CAS number | 33515-09-2 |
| Molecular formula | C55H75N17O13 |
| Theoretical mass | 1182.3 Da |
| Sequence / structure | pGlu-HWSYGLRPG-NH₂ (10 residues; N-terminal pyroglutamate; C-terminal amide) |
| Contents | Gonadorelin: 10 mg per bottle (≤ 0.1% w/v) |
| Form | Sterile aqueous solution in bacteriostatic water (0.9% benzyl alcohol), supplied in a metered nasal spray bottle |
| Storage, sealed | Store at 2–8 °C, protected from light; do not freeze |
| Format | Solution in a metered nasal spray bottle |
Sizes and lots
- 10 mg · 1 bottle — $118.99
- 10 mg · Kit of 10 — $1057.82
Gonadorelin is gonadotropin-releasing hormone made by synthesis, with the same ten residues as the peptide the hypothalamus releases to drive LH and FSH secretion. This listing holds 10 mg of it already dissolved in bacteriostatic water, in a metered nasal spray bottle. Research on GnRH is mostly about its pituitary receptor and about how pulsed and continuous exposure produce very different pituitary responses; the nasal route is not covered by the papers cited here.
What is in the bottle
The bottle holds a sterile solution of gonadorelin in bacteriostatic water with 0.9% benzyl alcohol as a preservative: 10 mg of peptide per bottle, at no more than 0.1% w/v according to the safety data sheet. The peptide is the same native sequence sold in the vial, pGlu-HWSYGLRPG-NH2, with a theoretical mass of 1182.3 Da.
The sheet lists gonadorelin as a respiratory sensitizer (H334) and skin sensitizer (H317), harmful if inhaled (H332), a suspected reproductive toxicant (H361) and a cause of organ damage through prolonged or repeated exposure (H372), so a spray needs care in the laboratory to avoid breathing it or getting it on skin. Benzyl alcohol adds eye irritation and skin sensitization. Store the bottle upright and capped at 2 to 8 °C, away from light, and never freeze it. General guidance on peptide solutions is in peptide storage and stability.
What the research covers
GnRH acts on the type I GnRH receptor of the pituitary, which signals mainly through the G protein Gq; Millar's review also described coupling to other G proteins and suggested that the structure of the ligand may influence which pathway the receptor uses1. What sets the hormone apart is its dependence on rhythm. In rhesus monkeys with hypothalamic lesions, Belchetz and colleagues found that continuous GnRH did not restore sustained gonadotropin secretion while intermittent GnRH did, and that moving restored animals onto continuous delivery could desensitize the response2.
None of the references cited here studied gonadorelin given through the nose, so how much of an 1182.3 Da peptide crosses the nasal lining, and in what pattern, is not established by them. The gonadorelin guide discusses a small 1977 human study of the intranasal route, and the general question of whether peptide sprays deliver anything is discussed in do peptide nasal sprays work. The full literature on the hormone, from its sequence to its diagnostic history, is in the gonadorelin guide.
Frequently asked questions
Is the spray the same peptide as the 2 mg vial?
Yes, the same native GnRH sequence with its pyroglutamate and amide ends. The difference is form: the vial is dry powder stored frozen, while the spray is a ready-made solution in bacteriostatic water that must be kept cold and never frozen.
Has gonadorelin been studied as a nasal spray?
Not in the papers cited on this page, which cover the GnRH receptor and a primate study of pulsed delivery. The gonadorelin guide describes an older, small human study of the nasal route, but these references give no data on how much peptide crosses the nasal lining.
References
- Millar RP, Lu ZL, Pawson AJ, et al. Gonadotropin-releasing hormone receptors. Endocr Rev. 2004;25(2):235-75. DOI · PubMed
- Belchetz PE, Plant TM, Nakai Y, et al. Hypophysial responses to continuous and intermittent delivery of hypopthalamic gonadotropin-releasing hormone. Science. 1978;202(4368):631-3. DOI · PubMed
For laboratory research use only. Not for human or veterinary consumption. Products have not been evaluated by the U.S. Food and Drug Administration and are not intended to diagnose, treat, cure or prevent any disease.