Ipamorelin Nasal Spray
10 mg of the five-residue growth hormone secretagogue as a sterile solution in bacteriostatic water, in a metered spray bottle. Made from a peptide lot tested in the manufacturer’s own laboratory, with a certificate.
| Compound | Ipamorelin NNC 26-0161; selective growth hormone secretagogue pentapeptide |
|---|---|
| CAS number | 170851-70-4 |
| Molecular formula | C38H49N9O5 |
| Theoretical mass | 711.9 Da |
| Sequence / structure | H-Aib-H-[D-2-Nal]-[D-Phe]-K-NH₂ (5 residues; C-terminal amide) |
| Contents | Ipamorelin: 10 mg per bottle (≤ 0.1% w/v) |
| Form | Sterile aqueous solution in bacteriostatic water (0.9% benzyl alcohol), supplied in a metered nasal spray bottle |
| Storage, sealed | Store at 2–8 °C, protected from light; do not freeze |
| Format | Solution in a metered nasal spray bottle |
Sizes and lots
- 10 mg · 1 bottle — $58.99
- 10 mg · Kit of 10 — $524.42
Ipamorelin is a synthetic five-residue growth hormone secretagogue that acts on the ghrelin receptor. This listing is a nasal spray bottle holding 10 mg of the peptide as a sterile solution in bacteriostatic water, ready to use without reconstitution. Research on ipamorelin itself comes from cell, rat and pig studies of growth hormone release and selectivity, while the case for the nasal route rests on a separate literature about peptides in general.
What is in the bottle
Each bottle holds 10 mg of ipamorelin, the same Aib-His-D-2-Nal-D-Phe-Lys-NH₂ sold in the vials, at no more than 0.1% w/v (1 mg/mL). It is dissolved in bacteriostatic water, which contains 0.9% benzyl alcohol as an antimicrobial preservative, with water for injection making up the balance. The safety data sheet lists ipamorelin as a skin and eye irritant that may cause respiratory irritation (H315, H319, H335), and benzyl alcohol as harmful if swallowed or inhaled, an eye irritant and a possible skin sensitiser.
Store the bottle upright and capped at 2 to 8 °C, away from light, and never freeze it. For a concentration you set yourself, the Ipamorelin 10 mg vial holds dry peptide that can be dissolved in any volume. General guidance on peptide solutions is in peptide storage and stability.
What the research covers
Ipamorelin came out of a chemistry programme on analogues of growth hormone-releasing peptide-1 that lack its central Ala-Trp pair1. In rat pituitary cells it released growth hormone almost as effectively as GHRP-6, and antagonist experiments placed its action at the GHRP receptor rather than the GHRH receptor1. In swine, GHRP-6 and GHRP-2 raised ACTH and cortisol while ipamorelin did not go beyond the levels seen after GHRH, which is why the authors called it the first selective growth hormone secretagogue1. Its receptor had been cloned two years earlier from pig and human pituitary and hypothalamus as the target of the synthetic secretagogues, at a time when its natural ligand was still unknown2.
The nasal route raises separate questions. Illum's 2002 review described rising pharmaceutical interest in nasal delivery for peptides and other hard-to-deliver drugs, and discussed evidence that some drugs pass directly from the nose to the brain along the olfactory pathway, with proof-of-concept examples in people3. None of the papers cited here studied ipamorelin given by the nasal route, so how much of a 711.9 Da peptide crosses the nasal lining, and where it goes, is not established. The full literature on the peptide is in sermorelin vs ipamorelin vs tesamorelin.
Frequently asked questions
Is the spray the same peptide as the ipamorelin vials?
Yes, the same five-residue sequence with a C-terminal amide and a theoretical mass of 711.9 Da. The vials are dry powder kept at −20 °C; the spray is a ready-made solution in bacteriostatic water that is kept cold but never frozen.
How much ipamorelin is in one bottle?
10 mg, at no more than 0.1% w/v according to the safety data sheet. The amount and concentration are also on the bottle label. Where a study needs a different concentration, the 5 mg and 10 mg vials can be dissolved in whatever volume the work calls for.
Has ipamorelin been studied as a nasal spray?
Not in any paper cited on this page. The nasal delivery review covers peptides and other drugs in general, and the ipamorelin papers used other routes, so there are no published findings specific to this format to point to.
References
- Raun K, Hansen BS, Johansen NL, et al. Ipamorelin, the first selective growth hormone secretagogue. Eur J Endocrinol. 1998;139(5):552-61. DOI · PubMed
- Howard AD, Feighner SD, Cully DF, et al. A receptor in pituitary and hypothalamus that functions in growth hormone release. Science. 1996;273(5277):974-7. DOI · PubMed
- Illum L. Nasal drug delivery: new developments and strategies. Drug Discov Today. 2002;7(23):1184-9. DOI · PubMed
For laboratory research use only. Not for human or veterinary consumption. Products have not been evaluated by the U.S. Food and Drug Administration and are not intended to diagnose, treat, cure or prevent any disease.