Ovagen Nasal Spray
20 mg of the Khavinson tripeptide Glu-Asp-Leu (EDL) as a sterile solution in bacteriostatic water, in a metered spray bottle. Made from a peptide lot tested in the manufacturer’s own laboratory, with a certificate.
| Compound | Ovagen Glu-Asp-Leu (EDL); Khavinson peptide bioregulator |
|---|---|
| CAS number | Not assigned |
| Molecular formula | C15H25N3O8 |
| Theoretical mass | 375.4 Da |
| Sequence / structure | H-EDL-OH (3 residues; free N- and C-termini) |
| Contents | Ovagen: 20 mg per bottle (≤ 0.2% w/v) |
| Form | Sterile aqueous solution in bacteriostatic water (0.9% benzyl alcohol), supplied in a metered nasal spray bottle |
| Storage, sealed | Store at 2–8 °C, protected from light; do not freeze |
| Format | Solution in a metered nasal spray bottle |
Sizes and lots
- 20 mg · 1 bottle — $118.99
- 20 mg · Kit of 10 — $1057.82
Ovagen nasal spray contains Glu-Asp-Leu, the synthetic EDL tripeptide of 375.4 Da from Vladimir Khavinson's short-peptide series. The bottle holds 20 mg of Ovagen as a sterile solution in bacteriostatic water, at no more than 0.2% w/v, so there is no powder to dissolve. Research on EDL itself is limited to cell and tissue cultures of kidney cells, while nasal delivery is a separate pharmaceutical field, and none of that work has tested EDL.
What is in the bottle
The bottle contains 20 mg of the same H-EDL-OH tripeptide sold freeze-dried in the Ovagen 20 mg vial, dissolved at or below 0.2% w/v in bacteriostatic water preserved with 0.9% benzyl alcohol. In molar terms that is about 53 µmol, as in the vial. The safety data sheet does not classify the peptide. Benzyl alcohol is listed as harmful by ingestion or inhalation, an eye irritant and a skin sensitiser.
Store the bottle upright with the cap on, at 2 to 8 °C and away from light, and do not let it freeze. General advice on peptide solutions is in peptide storage and stability.
What the research covers
Pharmaceutical interest in the nasal route is general rather than specific to this peptide. Illum's 2002 review described how drug delivery companies were developing nasal systems for conventional drugs and for peptides, and discussed the finding that some substances travel from the nose to the brain along the olfactory pathway1. The review is about delivery technology. It does not mention EDL or any Khavinson peptide, and none of the EDL papers used the nose.
EDL itself has been studied in culture. The Khavinson group's kidney work coded it T-35 and reported that, in tissue explants from the kidneys of young and old rats, it stimulated proliferation and reduced apoptosis, less strongly than a calf kidney peptide complex2. In aging primary kidney cell cultures the same group named the gelatinase MMP-14 as its target3. Neither study says anything about how the peptide behaves in a spray solution or whether it crosses a mucous membrane.
Frequently asked questions
Is the spray the same Ovagen as the vial and pen?
Yes. All three contain the synthetic tripeptide Glu-Asp-Leu. The vial is dry powder for storage at −20 °C, while the spray and the pen are ready-made solutions in bacteriostatic water that are kept cold and never frozen. The spray and the vial each hold 20 mg; the pen holds 6 mg.
How concentrated is the solution?
The safety data sheet gives 20 mg of Ovagen per bottle at no more than 0.2% w/v, and the bottle label states the amount. For work that needs a concentration chosen in the lab, the freeze-dried vial supplies a known mass of dry peptide instead.
Has EDL been studied as a nasal spray?
No. None of the EDL papers cited here involved the nasal route; they are culture studies of kidney cells. The nasal delivery review on this page concerns peptides and drugs in general and does not mention EDL.
References
- Illum L. Nasal drug delivery: new developments and strategies. Drug Discov Today. 2002;7(23):1184-9. DOI · PubMed
- Chalisova NI, Lin'kova NS, Nichik TE, et al. Peptide Regulation of Cells Renewal Processes in Kidney Tissue Cultures from Young and Old Animals. Bull Exp Biol Med. 2015;159(1):124-7. DOI · PubMed
- Khavinson VKh, Lin'kova NS, Polyakova VO, et al. Peptides regulate expression of signaling molecules in kidney cell cultures during in vitro aging. Bull Exp Biol Med. 2014;157(2):261-4. DOI · PubMed
For laboratory research use only. Not for human or veterinary consumption. Products have not been evaluated by the U.S. Food and Drug Administration and are not intended to diagnose, treat, cure or prevent any disease.