Ovagen Pen
3 mL of sterile solution in bacteriostatic water holding 6 mg of the Khavinson tripeptide at 2 mg/mL. Filled from a peptide lot tested in the manufacturer’s own laboratory, with a certificate.
| Compound | Ovagen Glu-Asp-Leu (EDL); Khavinson peptide bioregulator |
|---|---|
| CAS number | Not assigned |
| Molecular formula | C15H25N3O8 |
| Theoretical mass | 375.4 Da |
| Sequence / structure | H-EDL-OH (3 residues; free N- and C-termini) |
| Contents | Ovagen: 6 mg per 3 mL pen (0.2% w/v) |
| Form | Sterile aqueous solution in bacteriostatic water (0.9% benzyl alcohol), supplied in a 3 mL glass cartridge inside a preloaded autoinjector pen fitted with a needle |
| Storage, sealed | Store at 2–8 °C in the original carton, protected from light |
| Format | Solution in a 3 mL pre-filled pen |
Sizes and lots
- 6 mg · 1 pen — $48.99
- 6 mg · Kit of 10 — $435.52
Ovagen is Glu-Asp-Leu (EDL), a three-residue synthetic peptide from the Khavinson bioregulator series with a theoretical mass of 375.4 Da. In this listing it comes already dissolved in a preloaded pen: a 3 mL cartridge holding 6 mg of Ovagen at 0.2% w/v, which is 2 mg/mL. Published work on EDL amounts to a few kidney cell and tissue-culture studies from one St Petersburg group, set against that group's broader idea that short peptides regulate genes.
What is in the pen
The cartridge holds 3 mL of sterile solution. The peptide is the same H-EDL-OH sold as freeze-dried powder in the Ovagen 20 mg vial, here at 0.2% w/v: 6 mg per pen, or roughly 16 µmol. The solvent is bacteriostatic water with 0.9% benzyl alcohol as the preservative. On the safety data sheet the peptide is not classified as hazardous, while benzyl alcohol carries statements for harm if swallowed or inhaled, serious eye irritation and possible skin sensitisation.
Keep the pen in its carton at 2 to 8 °C, out of the light, capped between uses and never frozen. The sheet says to discard it if the solution has frozen or looks discoloured or cloudy. The pen holds less peptide than the vial or the spray, which both carry 20 mg. For the general trade-offs between formats, see peptide pen vs vial.
What the research covers
The tripeptide in the pen is coded T-35 in the papers of Khavinson's group, and the studies that test it directly used kidney cells. In primary kidney cell cultures aged in vitro, the group compared T-35 with the related tripeptide T-31 (AED) and with a calf kidney polypeptide complex; the abstract identifies the gelatinase MMP-14 as the target of T-35, while cell-renewal markers responded to the other two1. In organotypic kidney cultures from young and old rats, both tripeptides raised proliferation and lowered apoptosis, by less than the kidney complex did2.
Behind these sits the group's general model, in which peptides of two to seven residues reach the cell nucleus, interact with histones and DNA, and alter gene expression and methylation3. That model is stated for short peptides as a class. None of the abstracts measured EDL in a solution like the one in this pen, and none reports its stability in water, so the storage limits on the safety data sheet are the only guidance for the pen itself.
Frequently asked questions
How does the pen differ from the Ovagen vial?
The vial holds 20 mg of freeze-dried EDL that is kept at −20 °C and dissolved in the lab when needed. The pen holds 6 mg already in bacteriostatic water at 2 mg/mL and is kept at 2 to 8 °C. The peptide is the same; the amount, form and storage differ.
Is there published stability data for Ovagen in solution?
Not in the references checked for this page. The EDL papers are short culture studies that do not report how the peptide holds up in water over time, so the storage conditions on the safety data sheet are what to follow.
References
- Khavinson VKh, Lin'kova NS, Polyakova VO, et al. Peptides regulate expression of signaling molecules in kidney cell cultures during in vitro aging. Bull Exp Biol Med. 2014;157(2):261-4. DOI · PubMed
- Chalisova NI, Lin'kova NS, Nichik TE, et al. Peptide Regulation of Cells Renewal Processes in Kidney Tissue Cultures from Young and Old Animals. Bull Exp Biol Med. 2015;159(1):124-7. DOI · PubMed
- Khavinson VK, Popovich IG, Linkova NS, et al. Peptide Regulation of Gene Expression: A Systematic Review. Molecules. 2021;26(22). DOI · PubMed
For laboratory research use only. Not for human or veterinary consumption. Products have not been evaluated by the U.S. Food and Drug Administration and are not intended to diagnose, treat, cure or prevent any disease.