Prostamax Nasal Spray
20 mg of the Khavinson prostate tetrapeptide as a sterile solution in bacteriostatic water, in a metered spray bottle. Made from a peptide lot tested in the manufacturer’s own laboratory, with a certificate.
| Compound | Prostamax Lys-Glu-Asp-Pro (KEDP); Khavinson prostate peptide bioregulator |
|---|---|
| CAS number | Not assigned |
| Molecular formula | C20H33N5O9 |
| Theoretical mass | 487.5 Da |
| Sequence / structure | H-KEDP-OH (4 residues; free N- and C-termini) |
| Contents | Prostamax: 20 mg per bottle (≤ 0.2% w/v) |
| Form | Sterile aqueous solution in bacteriostatic water (0.9% benzyl alcohol), supplied in a metered nasal spray bottle |
| Storage, sealed | Store at 2–8 °C, protected from light; do not freeze |
| Format | Solution in a metered nasal spray bottle |
Sizes and lots
- 20 mg · 1 bottle — $118.99
- 20 mg · Kit of 10 — $1057.82
Prostamax, the Lys-Glu-Asp-Pro tetrapeptide (KEDP) from Vladimir Khavinson's bioregulator series, is supplied here as a sterile solution in a metered nasal spray bottle containing 20 mg of peptide. The series' developers designed it with the prostate in mind. Its research record is small, comes from St Petersburg, and covers chromatin in human leukocytes and the group's general model of gene regulation by peptides; none of it involved nasal delivery.
What is in the bottle
The bottle holds 20 mg of Prostamax in bacteriostatic water with 0.9% benzyl alcohol as a preservative, at no more than 0.2% w/v. In molar terms that is about 41 µmol, based on the certificate's theoretical mass of 487.5 Da. The safety data sheet leaves the peptide unclassified. Of the other ingredients only benzyl alcohol is classified: it is harmful if swallowed or inhaled, seriously irritates the eyes and can sensitise skin.
Keep the bottle upright and capped at 2 to 8 °C, protected from light, and do not freeze it. The same peptide is available as dry powder in the Prostamax 20 mg vial, and peptide storage and stability gives general guidance on keeping peptide solutions.
What the research covers
Prostamax is one of the short synthetic analogues that Khavinson's group made after isolating small peptides from organs and tissues1. In leukocytes from older people, it was among five peptides that activated ribosomal genes and released genes held in condensed chromatin2. It was also one of three, with Epitalon and Livagen, that decondensed the structural heterochromatin beside the centromere of chromosome 12. The abstract does not state how many donors were studied. The nuclear-entry experiments that the group cites for its mechanism used other peptides, Epitalon, Pinealon and Testagen, tracked with fluorescent labels in HeLa cells3. Khavinson is an author of all three papers, and the experimental ones were published in Russian journals in English translation. The mechanism they support is a hypothesis from one programme.
None of these papers studied the nose. No reference on this page addresses whether a 487.5 Da tetrapeptide crosses the nasal lining or what happens to it there, and none measured Prostamax's stability in solution. This format therefore has no published findings of its own; the storage conditions come from the safety data sheet. The Prostamax guide and the peptide bioregulators research overview give the wider background on the compound and its relatives.
Frequently asked questions
Is the spray the same Prostamax as the vial and pen?
Yes. All three contain the Lys-Glu-Asp-Pro tetrapeptide shown in the specifications. The vial holds it dry and frozen; the pen and the spray bottle hold it dissolved in bacteriostatic water, kept at 2 to 8 °C and never frozen.
Has Prostamax been studied as a nasal spray?
None of the cited papers tested it that way. The Prostamax work used human leukocytes, and the mechanism papers used other peptides in cultured cells. There are no published findings specific to a nasal format.
References
- Anisimov VN, Khavinson VKh. Peptide bioregulation of aging: results and prospects. Biogerontology. 2010;11(2):139-49. DOI · PubMed
- Khavinson VKh, Lezhava TA, Malinin VV. Effects of short peptides on lymphocyte chromatin in senile subjects. Bull Exp Biol Med. 2004;137(1):78-81. DOI · PubMed
- Fedoreyeva LI, Kireev II, Khavinson VKh, et al. Penetration of short fluorescence-labeled peptides into the nucleus in HeLa cells and in vitro specific interaction of the peptides with deoxyribooligonucleotides and DNA. Biochemistry (Mosc). 2011;76(11):1210-9. DOI · PubMed
For laboratory research use only. Not for human or veterinary consumption. Products have not been evaluated by the U.S. Food and Drug Administration and are not intended to diagnose, treat, cure or prevent any disease.